Remineralization: Recaldent (CPP-ACP)

Casein phosphopeptide, CPP is a milk protein that, when added to ACP, has stabilizing qualities.  This combined product, casein phosphopeptide and amorphous calcium phosphate (CCP-ACP) is known as Recaldent.  The combination of CPP and ACP gives the product a longer exposure time(substantivity) on the teeth compared to ACP alone.  CCP-ACP needs an acid challenge to release the calcium and phosphate ions that will buffer the saliva pH to neutral (6.5 to 7.4) to remineralize teeth. CCP-ACP is released during acid challenges raising the oral pH to 7.  CCP-ACP is found in MI Paste (GC America) and Trident Extra Care gum.  MI Paste Plus includes the addition of 900ppm fluoride forming calcium phosphate fluoride, CCP-ACFP.  The addition of fluoride to Recaldent has shown improved remineralizing properties over CCP-ACP alone.  

A useful feature of MI Paste is its slippery quality that xerostomia patients may find soothing and can be used throughout the day and night.  The non-fluoride version is perfectly safe for all age groups.  MI Paste Plus has 900 ppm fluoride so it should not be used in children under age six due to the risk of fluoride ingestion.  Recaldent should not be used by those allergic to milk proteins or benzoate preservatives.  From RDH Magazine